| UFC Fight Night: Santos vs. Hill | Jamahal Hill | 1070 →1095(+25) | Thiago Santos | 1096 →1072(-24) | Light Heavyweight | Loss | KO |
| UFC Fight Night: Santos vs. Ankalaev | Magomed Ankalaev | 1120 →1140(+20) | Thiago Santos | 1116 →1096(-20) | Light Heavyweight | Loss | U-DEC |
| UFC Fight Night: Santos vs. Walker | Thiago Santos | 1099 →1116(+17) | Johnny Walker | 1057 →1040(-17) | Light Heavyweight | Win | U-DEC |
| UFC 259: Blachowicz vs. Adesanya | Aleksandar Rakic | 1085 →1107(+22) | Thiago Santos | 1121 →1099(-22) | Light Heavyweight | Loss | U-DEC |
| UFC Fight Night: Santos vs. Teixeira | Glover Teixeira | 1181 →1201(+20) | Thiago Santos | 1141 →1121(-20) | Light Heavyweight | Loss | SUB |
UFC 239: Jones vs. Santos | Jon Jones | 1304 →1316(+12) | Thiago Santos | 1153 →1141(-12) | Light Heavyweight | Loss | S-DEC |
| UFC Fight Night: Blachowicz vs. Santos | Thiago Santos | 1134 →1153(+19) | Jan Blachowicz | 1066 →1047(-19) | Light Heavyweight | Win | KO |
| UFC 231: Holloway vs. Ortega | Thiago Santos | 1116 →1134(+18) | Jimi Manuwa | 1046 →1028(-18) | Light Heavyweight | Win | KO |
| UFC Fight Night: Marreta vs. Anders | Thiago Santos | 1096 →1116(+20) | Eryk Anders | 1046 →1026(-20) | Light Heavyweight | Win | KO |
| UFC 227: Dillashaw vs. Garbrandt 2 | Thiago Santos | 1081 →1096(+15) | Kevin Holland | 1000 →984(-16) | Middleweight | Win | U-DEC |
| UFC Fight Night: Barboza vs. Lee | David Branch | 1010 →1040(+30) | Thiago Santos | 1110 →1081(-29) | Middleweight | Loss | KO |
| UFC Fight Night: Machida vs. Anders | Thiago Santos | 1090 →1110(+20) | Anthony Smith | 1049 →1029(-20) | Middleweight | Win | KO |
| UFC Fight Night: Brunson vs. Machida | Thiago Santos | 1069 →1090(+21) | Jack Hermansson | 1043 →1021(-22) | Middleweight | Win | KO |
| UFC 213: Romero vs. Whittaker | Thiago Santos | 1046 →1069(+23) | Gerald Meerschaert | 1044 →1021(-23) | Middleweight | Win | KO |
| UFC Fight Night: Lewis vs. Browne | Thiago Santos | 1022 →1046(+24) | Jack Marshman | 1027 →1003(-24) | Middleweight | Win | KO |
| UFC Fight Night: Cyborg vs. Lansberg | Eric Spicely | 977 →1005(+28) | Thiago Santos | 1050 →1022(-28) | Middleweight | Loss | SUB |
| UFC 200: Tate vs Nunes | Gegard Mousasi | 1062 →1085(+23) | Thiago Santos | 1074 →1050(-24) | Middleweight | Loss | KO |
| UFC 198: Werdum vs Miocic | Thiago Santos | 1050 →1074(+24) | Nate Marquardt | 1066 →1042(-24) | Middleweight | Win | KO |
| UFC Fight Night: Namajunas vs. VanZant | Thiago Santos | 1028 →1050(+22) | Elias Theodorou | 1062 →1040(-22) | Middleweight | Win | U-DEC |
| UFC Fight Night: Machida vs Romero | Thiago Santos | 1005 →1028(+23) | Steve Bosse | 1000 →977(-23) | Middleweight | Win | KO |
| UFC 183: Silva vs Diaz | Thiago Santos | 984 →1005(+21) | Andy Enz | 963 →941(-22) | Middleweight | Win | KO |
| UFC 175: Weidman vs Machida | Uriah Hall | 988 →1009(+21) | Thiago Santos | 1005 →984(-21) | Middleweight | Loss | U-DEC |
| UFC Fight Night: Shogun vs Henderson 2 | Thiago Santos | 978 →1005(+27) | Ronny Markes | 1037 →1010(-27) | Middleweight | Win | KO |
| UFC 163: Aldo vs Jung | Cezar Ferreira | 1020 →1041(+21) | Thiago Santos | 1000 →978(-22) | Middleweight | Loss | SUB |
